{"product_id":"kpv-10mg","title":"KPV 10MG","description":"\u003cp\u003eDISCLAIMER:\u003cbr\u003eThis product is sold strictly for laboratory research purposes only. It is not intended for human consumption or medical use. By purchasing, you agree to use this product in compliance with all applicable laws and regulations. Peptide Fountain assumes no responsibility for misuse, and reserves the right to deny sale to any individual suspected of improper use.\u003c\/p\u003e\n\u003ch1 data-start=\"627\" data-end=\"665\"\u003eMechanism of Action (Key Science)\u003c\/h1\u003e\n\u003cp data-start=\"666\" data-end=\"779\"\u003eKPV is interesting because it works \u003cstrong data-start=\"702\" data-end=\"745\"\u003eindependently of melanocortin receptors\u003c\/strong\u003e (so no tanning\/appetite effects).\u003c\/p\u003e\n\u003ch3 data-start=\"781\" data-end=\"824\"\u003e1. NF-κB Inhibition (Primary Mechanism)\u003c\/h3\u003e\n\u003cul data-start=\"825\" data-end=\"1049\"\u003e\n\u003cli data-start=\"825\" data-end=\"897\"\u003eBlocks activation of \u003cstrong data-start=\"848\" data-end=\"857\"\u003eNF-κB\u003c\/strong\u003e, a major inflammation “master switch”\u003c\/li\u003e\n\u003cli data-start=\"898\" data-end=\"954\"\u003ePrevents transcription of pro-inflammatory cytokines\u003c\/li\u003e\n\u003cli data-start=\"955\" data-end=\"1049\"\u003eReduces:\n\u003cul data-start=\"968\" data-end=\"1049\"\u003e\n\u003cli data-start=\"968\" data-end=\"977\"\u003eTNF-α\u003c\/li\u003e\n\u003cli data-start=\"980\" data-end=\"989\"\u003eIL-1β\u003c\/li\u003e\n\u003cli data-start=\"992\" data-end=\"1000\"\u003eIL-6\u003c\/li\u003e\n\u003cli data-start=\"1003\" data-end=\"1049\"\u003eIL-8 \u003cspan class=\"\" data-state=\"closed\"\u003e\u003c\/span\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp data-start=\"1051\" data-end=\"1120\"\u003e👉 This is the same pathway targeted by many anti-inflammatory drugs.\u003c\/p\u003e\n\u003chr data-start=\"1122\" data-end=\"1125\"\u003e\n\u003ch3 data-start=\"1127\" data-end=\"1162\"\u003e2. Cytokine \u0026amp; Immune Modulation\u003c\/h3\u003e\n\u003cul data-start=\"1163\" data-end=\"1346\"\u003e\n\u003cli data-start=\"1163\" data-end=\"1203\"\u003eDecreases pro-inflammatory signaling\u003c\/li\u003e\n\u003cli data-start=\"1204\" data-end=\"1259\"\u003eMay increase anti-inflammatory cytokines like IL-10\u003c\/li\u003e\n\u003cli data-start=\"1260\" data-end=\"1346\"\u003eReduces neutrophil and macrophage activation \u003cspan class=\"\" data-state=\"closed\"\u003e\u003c\/span\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-start=\"1348\" data-end=\"1351\"\u003e\n\u003ch3 data-start=\"1353\" data-end=\"1399\"\u003e3. Inflammasome + Oxidative Stress Effects\u003c\/h3\u003e\n\u003cul data-start=\"1400\" data-end=\"1538\"\u003e\n\u003cli data-start=\"1400\" data-end=\"1458\"\u003eDownregulates \u003cstrong data-start=\"1416\" data-end=\"1456\"\u003eIL-1β \/ IL-18 (inflammasome pathway)\u003c\/strong\u003e\n\u003c\/li\u003e\n\u003cli data-start=\"1459\" data-end=\"1538\"\u003eReduces reactive oxygen species (ROS) \u003cspan class=\"\" data-state=\"closed\"\u003e\u003c\/span\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-start=\"1540\" data-end=\"1543\"\u003e\n\u003ch3 data-start=\"1545\" data-end=\"1584\"\u003e4. PepT1 Transport (Unique Feature)\u003c\/h3\u003e\n\u003cul data-start=\"1585\" data-end=\"1762\"\u003e\n\u003cli data-start=\"1585\" data-end=\"1647\"\u003eUses \u003cstrong data-start=\"1592\" data-end=\"1634\"\u003eintestinal peptide transporter (PepT1)\u003c\/strong\u003e for uptake\u003c\/li\u003e\n\u003cli data-start=\"1648\" data-end=\"1762\"\u003eThis is why it shows \u003cstrong data-start=\"1671\" data-end=\"1702\"\u003eoral activity in gut models\u003c\/strong\u003e (rare for peptides)\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Peptide Fountain ","offers":[{"title":"Default Title","offer_id":41891120578637,"sku":"","price":45.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0580\/0545\/4925\/files\/kpv-10-mg-vial.png?v=1772888255","url":"https:\/\/wenexus.co\/es\/products\/kpv-10mg","provider":"WeNexus","version":"1.0","type":"link"}